提出一种光透过散射介质的散斑恢复算法,可实现大视场任意位置的聚焦。通过仿真模拟光路测量散射介质的传输矩阵并进行二值化处理,再利用数字微镜器件对入射光进行二值振幅调制,实现透过散射介质的单点或多点聚焦。由于不同聚焦位置的独立性,所提算法能够实现大视场任意位置聚焦。仿真结果表明:聚焦位置的光强增强因子随着采样数目的增加而增加;与传统三步相移法相比,在采样数目减少1/3的情况下,所提算法能够获得55%的增强比,比三步相移法高12%。所提算法对透过散射介质实现大视场范围扫描聚焦有重要意义,在生物医学成像领域具有广阔应用前景。

Two-photon microscopy normally suffers from the scattering of the tissue in biological imaging. Multidither coherent optical adaptive technique (COAT) can correct the scattered wavefront in parallel. However, the determination of the corrective phases may not be completely accurate using conventional method, which undermines the performance of this technique. In this paper, we theoretically demonstrate a method that can obtain more accurate corrective phases by determining the phase values from the square root of the fluorescence signal. A numerical simulation model is established to study the performance of adaptive optics in two-photon microscopy by combining scalar diffraction theory with vector diffraction theory. The results show that the distortion of the wavefront can be corrected more thoroughly with our method in two-photon imaging. In our simulation, with the scattering from a 450-μm-thick mouse brain tissue, excitation focal spots with higher peak-to-background ratio (PBR) and images with higher contrast can be obtained. Hence, further enhancement of the multidither COAT correction performance in two-photon imaging can be expected.

介绍了磁光电混合存储的技术特点及发展历程;总结了其关键技术及研究现状,包括存储系统结构、软件和硬件的关键技术以及相关标准的制定和专利申请;介绍了混合存储技术的发展动向,对磁光电混合存储的技术发展进行了展望。该综述有助于研究人员更系统、清晰、准确地认识磁光电混合存储技术,并有助于未来大数据存储的发展。